Projects

IMPRINT network supports scientific as well as public engagement projects. Since 2017, we have been able to support a range of scientific activities which are organised around six thematic challenges representing the network’s focus areas. The public engagement projects' purpose is to facilitate imaginative, high-quality and inclusive public engagement which reaches new, global and diverse audiences. All ongoing and completed scientific and public engagement projects are listed below.

Challenge 1
Mechanism of production and transfer of maternal antibody via the placenta and breast milk

Progression Grant N°3: Linking IgG Fc Glycosylation with Functional Insights and Placental Transfer Mechanisms to Explain Group B Streptococcal Antibody Diversity

Fellowship N°2 Towards the understanding of anti-Group B Streptococcus (GBS) protective immunity: characterisation of maternal sera in high- vs. low- GBS prevalence countries using humanised mice

Pump priming project N°1: Unravelling maternal protection: Factors affecting transplacental transfer of antibody from mother to infant

Pump priming project N°6: The human placental perfusion model: advance in knowledge of maternofetal antibody transfer

Pump priming project N°10: Maternal transplacental antibody decay rates: an individual participant data meta-analysis

Challenge 2
Effects of maternal immunisation on the subsequent development of immunity in the infant

Progression Grant N°2: Using a systems serology approach to understand the persistence, quantity and quality of vaccine-induced maternal antibody responses and their impact on the infant’s immune response to childhood vaccines

Fellowship N°1 Understanding interactions between Maternal IgG and Neonatal Innate Immune Cells (MINIC)

Pump priming project N°3: Elucidating the effect of maternal immunisation on the subsequent development of T cell response following pertussis vaccination in infants

Pump priming project N°5: Oral vaccines which generate immune responses in the vagina and prevent mother-to-baby transmission of infections during birth

Challenge 3
Impact of globally important co-factors on maternal and neonatal immunity

Progression Grant N°1: Longitudinal Assessment of B and T Cell Immune Responses and Antibody Development to Pertussis Antigens in HIV-Positive Ugandan Pregnant Women Following Tdap Vaccination

Progression Grant N°4: Maternal iron and neonatal immunity – determinants of placental antibody transfer in pregnant women on the Thai-Myanmar border after vaccination and iron supplementation

Pump priming project N°7: How does iron influence infant immune development? A systems immunology RCT sub-study in Bangladeshi infants

Pump priming project N°11: IMPROVE - IMmunology of PRObiotics supplementation on Vaccine outcomes in Early life

Pump priming project N°12: Impact of early-life virome composition on oral rotavirus vaccine outcome among infants in the UK and Malawi

Challenge 4
Vaccine acceptancy and preparedness for maternal immunisation, including in emergencies

Fellowship N°4: Understanding the influence of public, provider, policy and contextual factors on maternal vaccine acceptance

Pump priming project N°2: Evaluating the Field Performance and Validating Novel Case Definitions Designed to Harmonize Safety Monitoring for Immunization in Pregnancy in LMIC

Pump priming project N°8: Assessing community acceptancy and health facility preparedness for implementation of maternal immunisation programs in urban and rural South Africa.

Challenge 5
Vaccine safety monitoring in LMIC

Fellowship N°3: Innovations for vaccine safety monitoring and improved maternal and neonatal immunization in rural Uganda (InVxSIM)

Challenge 6
Development of comparable methodologies for assessing efficacy in clinical trials

Pump priming project N°4: Using in vitro mycobacterial growth inhibition assays as a tool to assess functional immune responses induced by VPM1002 vaccination in infants

Public Engagement Projects

Development of a freely accessible computer game modelling vaccines versus infections

Empowering Traditional Birth Attendants to increase the utilization of maternal and neonatal immunizations in Imo State, Nigeria

Effect of information, education and communication interventions on awareness, risk perception and confidence in the uptake of maternal vaccination in Ebonyi State, Nigeria

Promoting Awareness on Maternal Vaccines (PAM)

Capturing and exchanging multi-national perceptions of maternal and neonatal immunisation

Building confidence on maternal vaccination by addressing risk perceptions using magnet theatre in rural and informal settlements in Kenya

Increasing maternal immunisation awareness by working with women influencers in Kawempe Division, Uganda

Improving maternal vaccination awareness in remote areas of the Kilimanjaro region in Tanzania

"Operation thrive" – An innovative community-based initiative in tribal areas of India to improve maternal and neonatal health

Establishing a pool of school-going adolescent girls and boys as immunisation ambassadors in Entebbe, Uganda

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